BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention

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BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention

As regards the interesting discovery of a novel BRCA1 mutation in a family of Palestinian Arabian origin (Kadouri et al., 2007), we would like to state that all gene mutations bring about necessarily local biological activity modification, otherwise, gene mutations would be meaningless innocent bystanders (Stagnaro-Neri and Stagnaro, 1995; Kadouri et al., 2007; Stagnaro, 2008). In the present a...

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Carcinogenesis and Effect of BRCA-1 and BRCA-2 Mutation on Breast Cancer Development

Cancer is the most important factor of death after cardiovascular diseases in human populations. So, the reserachers consider cancer as a factor of 13% of deaths that occur in the world. However, breast cancer is the most common type of cancer in women. Statistics show that the number of patients referred to America's Breast Cancer Clinic increased from 3745 in 2003 to 6671 in 2009 and cases of...

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BRCA 1, BRCA 2 models.

Anticipating that genetic tests designed to determine an individuals predisposition to disease would eventually become commercially available, and recognizing that the results of many of these tests may have mortality implications, in 1994 Lincoln National Reinsurance Companies began developing a methodology that would allow the mortality risk associated with a number of different genetic mutat...

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Clinical characteristics of laryngeal cancer in BRCA-1 mutation carriers.

BACKGROUND The aim of this study was to analyze the occurrence of clinical features characteristic of breast cancer type 1 susceptibility protein (BRCA-1)-dependent tumors in a series of BRCA-1 mutation carriers with laryngeal cancer. PATIENTS AND METHODS The clinical features of five laryngeal cancer patients with BRCA-1 mutations registered in our center were analyzed for: sex, age at diagn...

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BRCA in breast cancer: ESMO clinical recommendations.

Familial susceptibility to breast cancer accounts for 25% of all breast cancer cases. In familial breast cancer, mutations in the BRCA1, BRCA2, CHEK2, TP53 and PTEN genes account for 5–10% of breast and ovarian cancer cases overall. The prevalence of BRCA1 or BRCA2 mutations varies considerably between ethnic groups and geographical areas. Populationspecific mutations have been described in Ice...

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ژورنال

عنوان ژورنال: Frontiers in Genetics

سال: 2013

ISSN: 1664-8021

DOI: 10.3389/fgene.2013.00039